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Original Article
- Accelerated and Exacerbated Effects of High Dietary Fat on Neuronal Damage Induced by Transient Cerebral Ischemia in the Gerbil Septum
- Seung Hwan Cheon, Bing Chun Yan, Bai Hui Chen, Joon Ha Park, Ji Hyeon Ahn, In Hye Kim, Jae-Chul Lee, Yoo Seok Park, Min Joung Kim, Yun Lyul Lee, Jun Hwi Cho, Moo-Ho Won
- Endocrinol Metab. 2014;29(3):328-335. Published online September 25, 2014
- DOI: https://doi.org/10.3803/EnM.2014.29.3.328
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- 29 Download
- 8 Web of Science
- 8 Crossref
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Abstract
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PubReader Background Obesity induced by high-fat diet (HFD) is one of the most widespread metabolic disorders in current society. However, there has been little research regarding the effects of HFD-induced obesity in the septa of animal models of cerebral ischemia. Therefore, in the present study, we investigated septal effects of HFD on neuronal damage and gliosis induced by transient cerebral ischemia.
Methods Body weight, blood glucose levels and serum lipid profiles levels were measured both in the normal diet (ND) and HFD-group. We also investigated the effects of ND and HFD on neuronal damage and gliosis in the septum after transient cerebral ischemia using immunohistochemistry.
Results The levels of blood glucose, serum triglyceride, and total cholesterol were significantly increased in the HFD-fed gerbils compared with the ND-fed gerbils, although body weight was not significantly changed after HFD feeding. In the ND-fed gerbils, ischemia-induced neuronal damage was found in the septohippocampal nucleus (SHN) of the septum 7 days after ischemia. In the HFD-fed gerbils, ischemia-induced neuronal damage in the SHN was much more severe compared with that of the ND-fed gerbils 4 and 7 days after ischemia. In addition, we found that ischemia-induced glial activation including astrocytes and microglia was accelerated and exacerbated in the HFD-fed gerbils compared with that in the ND-fed gerbils.
Conclusion These results indicate that HFD can lead to much more severe effects in ischemia-induced neuronal damage/death in the septum after ischemia-reperfusion, and that it may be associated with accelerated change in glial activation.
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Citations
Citations to this article as recorded by
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Brain Research Bulletin.2020; 156: 15. CrossRef - High fat diet accelerates and exacerbates microgliosis and neuronal damage/death in the somatosensory cortex after transient forebrain ischemia in gerbils
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Laboratory Animal Research.2020;[Epub] CrossRef - A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation
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Kathleen E. Fifield, Todd M. Rowe, Joanna B. Raman-Nair, Michiru Hirasawa, Jacqueline L. Vanderluit
Neuroscience.2019; 406: 637. CrossRef - Antioxidant Properties of Fucoidan Alleviate Acceleration and Exacerbation of Hippocampal Neuronal Death Following Transient Global Cerebral Ischemia in High-Fat Diet-Induced Obese Gerbils
Ji Ahn, Myoung Shin, Dae Kim, Hyunjung Kim, Minah Song, Tae-Kyeong Lee, Jae-Chul Lee, Hyeyoung Kim, Jun Cho, Young-Myeong Kim, Jong-Dai Kim, Soo Choi, Moo-Ho Won, Joon Park
International Journal of Molecular Sciences.2019; 20(3): 554. CrossRef - Obesity and stroke: Can we translate from rodents to patients?
Michael J Haley, Catherine B Lawrence
Journal of Cerebral Blood Flow & Metabolism.2016; 36(12): 2007. CrossRef - Articles in 'Endocrinology and Metabolism' in 2014
Won-Young Lee
Endocrinology and Metabolism.2015; 30(1): 47. CrossRef
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